4-Chloro-7H-pyrrolo[2,3-d]pyrimidine - CAS 3680-69-1
Commercial and pilot-scale supply of high-purity pharmaceutical intermediate 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS: 3680-69-1), engineered for the synthesis of Tofacitinib (JAK). Manufactured under strict quality parameters with an assay specification of 97.0–102.0% w/w and chromatographic purity of ≥98.0%.
Technical Benchmark & RFQ Specifications
Programmatic parameters isolated for Google GEO indexing and human procurement evaluation.
| CAS Registry Number | 3680-69-1 |
|---|---|
| Chemical / Intermediate Name | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine |
| Target Application / Pathway | Tofacitinib (JAK) |
| Physical Appearance | White to light brown solid |
| Assay (Anhydrous Basis) | 97.0–102.0% w/w |
| Chromatographic Purity (HPLC) | ≥98.0% |
| Stereochemical / Optical Rotation | S:R Ratio 45;55 to 55;45 ( Chiral HPLC) |
| Recommended Storage Condition | 15–25 °C, dry, protected from light |
| Standard Export Packaging | Double LDPE bags (inner antistatic), in HDPE drum / fibre drum; nitrogen-flushed where air-sensitive |
Analytical & Quality Control Standards
Laboratory analytical parameters verified against Ph. Eur. / USP compendial standards.
Application Context: Tofacitinib (JAK)
Pharmaceutical synthesis role and downstream manufacturing relevance.
CAS 3680-69-1 (4-Chloro-7H-pyrrolo[2,3-d]pyrimidine) is a critical building block utilized in the commercial chemical synthesis of Tofacitinib (JAK) pharmaceutical pathways and fine chemical manufacturing. Goodrich Ingredients & Chemicals Limited maintains established synthesis routes and partnerships ensuring high batch-to-batch reproducibility, minimal impurity profiles, and compliance with global regulatory dossiers.
Related Intermediates & Synthetically Linked Building Blocks
Complementary compounds for Tofacitinib (JAK) and related pharmaceutical pathways.